Identification of complex genomic rearrangements in cancers using CouGaR
نویسندگان
چکیده
منابع مشابه
nFuse: Discovery of complex genomic rearrangements in cancer using high-throughput sequencing
Complex Genomic Rearrangements (CGRs) are emerging as a new feature of cancer genomes. CGRs are characterized by multiple genomic breakpoints, and thus have the potential to simultaneously affect multiple genes, fusing some genes and interrupting other genes. Analysis of high-throughput whole genome shotgun sequencing (WGSS) is beginning to facilitate the discovery and characterization of CGRs,...
متن کاملnFuse: Discovery of complex genomic rearrangements in cancer using high-throughput sequencing Supplementary Text
Supplemental nFuse pipeline overview The nFuse method builds upon Comrad (McPherson et al., 2011b), our previous work on rearrangement detection in matched RNA-seq and WGSS. We begin this section by briefly describing Comrad, then describe significant differences between Comrad and nFuse. An overview of the nFuse pipeline is shown in Figure 1.
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Complex genomic rearrangements (CGRs) are emerging as a new feature of cancer genomes. CGRs are characterized by multiple genomic breakpoints and thus have the potential to simultaneously affect multiple genes, fusing some genes and interrupting other genes. Analysis of high-throughput whole-genome shotgun sequencing (WGSS) is beginning to facilitate the discovery and characterization of CGRs, ...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2016
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.211201.116